NJPW Dominion 6.6 in Osaka-jō Hall was a professional wrestling event promoted by New Japan Pro-Wrestling (NJPW) that took place on June 7, 2021, at Osaka-jō Hall in Osaka, Japan, headlined by Kazuchika Okada vs. Shingo Takagi for the vacant IWGP World Heavyweight Championship.

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Main Cast: Shin Takagi, Kazuchika Okada, Kota Ibushi, Jeffrey Cobb, Kyosuke Mikami, Yohei Komatsu, Seiya Sanada, Tetsuya Naito, Tetsuya Shimizu, Luke James Uggles Eatwell

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