Sakura Genesis 2021 was a professional wrestling event promoted by New Japan Pro Wrestling (NJPW), which took place on April 4, 2021, at Ryōgoku Kokugikan in Tokyo, Japan.

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Main Cast: Kota Ibushi, William Ospreay, Kyosuke Mikami, Yoshinobu Kanemaru, Sho Tanaka, Yohei Komatsu, Hiroshi Tanahashi, Satoshi Kojima, Fale Simitaitoko, Jamie White

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