UFC on ESPN 16: Holm vs. Aldana was a mixed martial arts event produced by the Ultimate Fighting Championship that took place on October 4, 2020 at the du Forum on Yas Island, Abu Dhabi, United Arab Emirates. A women's bantamweight bout between former UFC Women's Bantamweight Champion Holly Holm and Irene Aldana served as the event headliner.

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Main Cast: Holly Holm, Irene Aldana, Carlos Felipe, Yorgan de Castro, Germaine de Randamie, Julianna Peña, Kyler Phillips, Cameron Else, Dusko Todorovic, Dequan Townsend

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