UFC Fight Night 161: Joanna vs. Waterson was a mixed martial arts event produced by the Ultimate Fighting Championship that took place on October 12, 2019 at Amalie Arena in Tampa, Florida. A women's strawweight bout between former UFC Women's Strawweight Champion Joanna Jędrzejczyk and former Invicta FC Atomweight Champion Michelle Waterson served as the event headliner.

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Main Cast: Joanna Jędrzejczyk, Michelle Waterson-Gomez, Cub Swanson, Kron Gracie, Niko Price, James Vick, Amanda Ribas, Mackenzie Dern, Matt Frevola, Luis Peña

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