UFC Fight Night 159: Rodriguez vs. Stephens was a mixed martial arts event produced by the Ultimate Fighting Championship that took place on September 21, 2019 at Mexico City Arena in Mexico City, Mexico. The Ultimate Fighter: Latin America featherweight winner Yair Rodríguez and Jeremy Stephens served as the main event.

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Main Cast: Yair Rodríguez, Jeremy Stephens, Carla Esparza, Alexa Grasso, Askar Askarov, Brandon Moreno, Irene Aldana, Vanessa Melo, Steven Peterson, Martin Bravo

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