WEC 53: Henderson vs. Pettis was a mixed martial arts event held by World Extreme Cagefighting that took place on December 16, 2010 at Jobing.com Arena in the Phoenix suburb of Glendale, Arizona. The event was the first time that Zuffa has hosted an event in Arizona. This was the final WEC event before merging with UFC in 2011.

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Main Cast: Anthony Pettis, Benson Henderson, Dominick Cruz, Scott Jorgensen, Donald Cerrone, Chris Horodecki, Kamal Shalorus, Bart Palaszewski, Danny Downes, Tiequan Zhang

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