UFC 121: Lesnar vs. Velasquez was a mixed martial arts event held by the Ultimate Fighting Championship on October 23, 2010 at the Honda Center in Anaheim, California, United States.

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Main Cast: Cain Velasquez, Brock Lesnar, Jake Shields, Martin Kampmann, Diego Sanchez, Paulo Thiago, Matt Hamill, Tito Ortiz, Brendan Schaub, Gabriel Gonzaga

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