UFC Fight Night 22: Marquardt vs. Palhares was a mixed martial arts event held by the Ultimate Fighting Championship on September 15, 2010 at the Frank Erwin Center in Austin, Texas. The event also served as a lead in to the season premiere of The Ultimate Fighter: Team GSP vs. Team Koscheck.

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Main Cast: Nate Marquardt, Rousimar Christian Palhares, Charles Oliveira, Efrain Escudero, Jim Miller, Gleison Tibau, Cole Miller, Ross Pearson, Yves Edwards, John Gunderson

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