UFC on Fox 22: VanZant vs. Waterson was a mixed martial arts event promoted by the Ultimate Fighting Championship and held on December 17, 2016, at Golden 1 Center in Sacramento, California. A women's bout between Paige VanZant and former Invicta FC Atomweight Champion Michelle Waterson served as the event headliner.

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Main Cast: Michelle Waterson-Gomez, Paige VanZant, Mickey Gall, Sage Northcutt, Urijah Faber, Brad Pickett, Alan Jouban, Mike Perry, Paul Craig, Henrique da Silva

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