UFC Fight Night 21: Florian vs. Gomi was a mixed martial arts event held by the Ultimate Fighting Championship on March 31, 2010 at Bojangles Coliseum in Charlotte, North Carolina, This was the third time the UFC held an event in Charlotte, but the first since UFC 5.

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Main Cast: Kenny Florian, Takanori Gomi, Roy Nelson, Stefan Struve, Jorge Rivera, Nate Quarry, Ross Pearson, Dennis Siver, Andre Winner, Rafaello Oliveira

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