WEC 45: Cerrone vs. Ratcliff was a mixed martial arts event held by World Extreme Cagefighting that took place on December 19, 2009 at The Pearl at The Palms in Las Vegas, Nevada. It marked the first time the WEC has held back-to-back events at the The Pearl at The Palms.

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Main Cast: Donald Cerrone, Ed Ratcliff, Anthony Njokuani, Chris Horodecki, Joseph Benavidez, Rani Yahya, Scott Jorgensen, Takeya Mizugaki, Bart Palaszewski, Anthony Pettis

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