UFC 106: Ortiz vs. Griffin 2 was a mixed martial arts event held by the Ultimate Fighting Championship (UFC) on November 21, 2009 at the Mandalay Bay Events Center.

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Main Cast: Forrest Griffin, Tito Ortiz, Josh Koscheck, Anthony Johnson, Paulo Thiago, Jacob Volkmann, Antônio Rogério Nogueira, Luiz Cane, Amir Sadollah, Phil Baroni

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