ONE Fight Night 21: Eersel vs. Nicolas was a combat sport event produced by ONE Championship that took place on April 6, 2024, at Lumpinee Boxing Stadium in Bangkok, Thailand. A ONE Lightweight Kickboxing World Championship bout between current champion (also current ONE Lightweight Muay Thai World Champion) Regian Eersel and Alexis Nicolas headlined the event.

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Main Cast: Alexis Nicolas, Regian Eersel, Tye Ruotolo, Izaak Michell, Suablack Tor.Pran49, Vladimir Kuzmin, Ben Tynan, Duke Didier, Denis Purić, Jacob Smith

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