The PFL 1 mixed martial arts event for the 2021 season of the Professional Fighters League was held on April 23, 2021. This was the first regular season event of the tournament and included fights in the Featherweight and Lightweight divisions. The event was headlined by a lightweight clash between the former UFC and WEC Lightweight champion Anthony Pettis and the UFC veteran Clay Collard.

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Main Cast: Clay Collard, Anthony Pettis, Marcin Held, Natan Schulte, Movlid Khaybulaev, Lazar Stojadinovic, Bubba Jenkins, Lance Palmer, Brendan Loughnane, Sheymon Moraes

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