The PFL 4 mixed martial arts event for the 2021 season of the Professional Fighters League was held on June 10, 2021. This was the fourth regular season event of the tournament and included fights in the Featherweight and Lightweight divisions. Boxing champion and Olympic gold medalist Claressa Shields made her MMA debut in the main event against Brittney Elkin.

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Main Cast: Claressa Shields, Brittney Elkin, Clay Collard, Joilton Lutterbach, Bubba Jenkins, Bobby Moffett, Brendan Loughnane, Tyler Diamond, Natan Schulte, Alexander Martinez

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