UFC on ESPN 42: Thompson vs. Holland was a mixed martial arts event produced by the Ultimate Fighting Championship that took place on December 3, 2022, at Amway Center in Orlando, Florida, United States. A welterweight bout between former UFC Welterweight Championship challenger Stephen Thompson and Kevin Holland headlined the event.

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Main Cast: Stephen Thompson, Kevin Holland, Rafael dos Anjos, Bryan Barberena, Matheus Nicolau, Matt Schnell, Sergey Pavlovich, Tai Tuivasa, Roman Dolidze, Jack Hermansson

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